When it comes to managing pain, the first that comes to mind — is Dolo 650. It’s a popular and affordable pain reliever in India that you can buy without a doctor’s prescription in almost all pharmacies around the country. Let’s discover more about this “wonder” pill — why it’s so popular, how it works, what it is used for, and its precautions and warnings. 

Dolo 650 at first glance

Dolo 650 is an effective pain reliever and fever reducer. The pills block prostaglandin production in the brain, which is responsible for pain and fever. This widely popular treatment is used to relieve different kinds of acute pains, as well as symptoms of colds and flu. Dolo 650 shows good results in treating fever and symptoms of COVID-19. It became one of the most popular prescribed paracetamol-based medicine during the pandemic. 

Dolo 650 tablet should be taken no more than four times per 24 hours and can be used no longer than prescribed by a doctor. This medicine shouldn’t be taken on an empty stomach and should be taken with a glass of water to help the medicine dissolve faster. The tablets can usually be prescribed with other medications as a part of a comprehensive treatment plan.

Although Dolo 650 rarely causes side effects, sometimes patients can experience temporary effects such as nausea, stomach pain or vomiting. If any side effects occur or you have liver or kidney problems or allergies, please contact a Viveo health practitioner online before taking Dolo 650. The doctor will help you to find the proper dosage or different medication to relieve your pain or cold symptoms.  

Active ingredients of Dolo 650 

The main and the one active ingredient of Dolo 650 is 650 mg of Paracetamol (Acetaminophen). Paracetamol was created in 1877 by American chemist Harmon Northrop Morse and was used for the first time to treat patients with pain only ten years later by German physician Josef von Mering. Since then, it has become a very popular medication worldwide. 

Unfortunately, the mechanism of Paracetamol’s action isn’t well understood and researched yet. Dissolving in our stomach and absorbed into the blood, the main ingredient of Dolo 650 Paracetamol travels around the body starting quite a complex range of processes with different receptors and enzymes involved to make us unable to feel the pain.


Paracetamol is safe if taking medicine in the dosage prescribed by a doctor below a maximum amount over 24 hours. Taking too much paracetamol can cause severe health problems or even death. 

What health problems does Dolo 650 treat?

Thanks to the antipyretic effect, Dolo 650 can reduce fever induced by the prostaglandin release. Therefore this medicine is widely used to combat fever caused by seasonal cold, flu, COVID-19, or as a part of comprehensive treatment of other diseases. The analgesic effect of this medicine blocks pain-related signals in the brain, reducing the ability to feel the pain. Therefore doctors prescribe Dolo 650 tablets to treat different acute or chronic pains:

  • Headache;
  • Migraine; 
  • Toothache;
  • Sore throat;
  • Period pain;
  • Fibroids pain;
  • Muscle pain;
  • Backache;
  • Nerve pain;
  • Strains and sprains;
  • Inflammation due to arthritis. 

These are just examples of conditions that are successfully treated with Dolo 650, and if you have any doubts or concerns about taking Dolo 650 please consult with a Viveo doctor online to understand if it is safe for you to take the tablets.

Do you know how to use Dolo 650 properly?

We recommend using Dolo 650 in dosage and frequency advised by your health practitioner. The 24-hours dosage should always be below or equal to the dosage recommended by the tablet producer. The duration of the treatment should also be discussed with a doctor. If you need to take Dolo 650 long-term, a doctor should monitor your kidney and liver functions and blood component levels. 

How to take Dolo 650

Swallow the whole tablet. It’s not safe to divide tablets, crush or break them. If you need a smaller dosage — you have to consult with your doctor about it. It’s much safer for your stomach to take pills with food or with a glass of milk. Other recommendations for taking Dolo 650: 

  • It’s not recommended to take indigestion remedies before and after two hours of taking paracetamol-based pain relievers.
  • It’s not recommended to use Dolo 650 therapy and drink alcohol as it increases the risk of stomach problems.  

What to do if I missed a dose? 

A missed dose of Dolo 650 should be taken as soon as possible. But if it’s almost time to take the next dose, you can simply skip the missed dose and return to your regular treatment schedule. It’s important not to double doses. 

How Dolo 650 interacts with food or other medications

Dolo 650 is safe for taking in most situations, but if you have been prescribed medications for chronic diseases, addictions, allergies, breathing difficulties, or a rare, life-threatening condition, you should consult a doctor before taking tablets. 

Dolo 650 and food interactions

It’s not recommended to use paracetamol-based medications such as Dolo 650 with food that contains caffeine (coffee, tea, cola, or chocolate) and with an excessive amount of alcohol. 

Medicines interactions

Don’t ever use Paracetamol-based medicines with medications that contain Nimesulide, Oxyphenbutazone, Metamizole, Warfarin, Aspirin, Cholestyramine, Ibuprofen, Tizanidine, Domperidone, Metoclopramide. It can be life-threatening. 

Chronic conditions, pregnancy, and breastfeeding interactions

Alcoholism, liver and kidney diseases, pancreatitis, peptic ulcer, coronary artery disease, IBD, colitis, and severe cardiac conditions are some of the reasons to always consult a doctor prior to the Dolo 650 therapy. It’s recommended to speak with a doctor about taking pain relievers by pregnant mothers. However, Dolo 650 is completely safe during breastfeeding if taken as prescribed by a healthcare specialist. 

The best Dolo 650 alternatives

Even though Dolo 650 is affordable and available in almost all pharmacies you go to, it’s always good to know the alternative medications in case the pharmacy doesn’t have Dolo 650 currently, and you need to take it soon. 

The average price for Dolo 650 is ₹25 for 30 tablets in the dosage of 650 mg of Paracetamol. Indian pharmacies can offer you cheaper and more expensive alternatives in the same dosage of Paracetamol: Pyricool, Welset, PUC, Paragreat, Calpol, and others. Consult with your doctor before choosing the alternative to Dolo 650. 


Note: This blog post is revised by a practicing health care provider. However, it is NOT an action guide. This blog post was published for informational purposes ONLY. CONSULT WITH YOUR DOCTOR BEFORE TAKING ANY MEDICINE.